[HTML][HTML] Increased IL-17RA and IL-17RC in end-stage COPD and the contribution to mast cell secretion of FGF-2 and VEGF
AB Roos, M Mori, HK Gura, A Lorentz, L Bjermer… - Respiratory …, 2017 - Springer
Respiratory research, 2017•Springer
Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD),
and interleukin (IL)-17 signaling plays a role in disease progression. The expression,
localization and functional relevance of IL-17 receptor (R) A and IL-17RC was explored in
COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in
very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic
basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro …
and interleukin (IL)-17 signaling plays a role in disease progression. The expression,
localization and functional relevance of IL-17 receptor (R) A and IL-17RC was explored in
COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in
very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic
basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro …
Abstract
Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.
IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.
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