Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content
K Inada, T Shima, M Ito, A Ushijima, S Saito - Journal of reproductive …, 2015 - Elsevier
Regulatory (Treg) T cells play essential roles in the maintenance of allogeneic pregnancy in
mice and humans. Recent data show that Foxp3 expression occurs in both immuno-
suppressive Treg and-nonsuppressive effector T (Teff) cells upon activation in humans.
Samstein et al.(2012) reported that inducible Treg (iTreg) cells enforce maternal–fetal
tolerance in placental mammals. Therefore, we should reanalyze which types of Treg cell
play an important role in the maintenance of allogeneic pregnancy. In this study, we studied …
mice and humans. Recent data show that Foxp3 expression occurs in both immuno-
suppressive Treg and-nonsuppressive effector T (Teff) cells upon activation in humans.
Samstein et al.(2012) reported that inducible Treg (iTreg) cells enforce maternal–fetal
tolerance in placental mammals. Therefore, we should reanalyze which types of Treg cell
play an important role in the maintenance of allogeneic pregnancy. In this study, we studied …
